Limnipivirus B

The
Picornavirus
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Child level

Same level

Carp picornavirus 1 (CPV-1) or limnipivirus B1 (LimV-B1) infects the common carp (Cyprinus carpio), a freshwater fish. 7634 nt of the genome including 524 nt of the 5' UTR and 284 nt of the unusually long 3' UTR have been sequenced (Lange et al., 2012, 2014). Like bluegill picornavirus 1 (BGPV-1), CPV-1 is predicted to possess two 2A polypeptides both with NPG↓P motifs, the second of which is 133 aa in length.

Wenling bighead beaked sandfish picornavirus (MG600092) is closely related (~75% nt / ~82% aa identity in VP1) and is now designated limnipivirus B2 (LimV-B2).

Genome organisation

VPg+5'UTR^IRES-IV[1AB−1C−1D−2A1^npgp/2A2^npgp/2B−2C/3A−3B^VPg−3C^pro−3D^pol]3'UTR−poly(A)

References

Lange J., Dauber, M., Fichtner, D., Groth, M., Platzer, M., Wutzler, P. and Zell, R. (2012). Sequencing of carp picornavirus reveals a second fish picornavirus lineage. Europic 2012: XVII^th Meeting of the European Study Group on the Molecular Biology of Picornaviruses, Saint Raphaël, France, 3-7 June 2012.

Lange, J., Groth, M., Fichtner, D., Granzow, H., Keller, B., Walther, M., Platzer, M., Sauerbrei, A. and Zell, R. (2014). Virus isolate from carp: genetic characterisation reveals a novel picornavirus with two aphthovirus 2A-like sequences. J. Gen. Virol. 95: 80-90 [Epub 2013 Oct 12].

Shi M, Lin XD, Chen X, Tian JH, Chen LJ, Li K, Wang W, Eden JS, Shen JJ, Liu L, Holmes EC, Zhang YZ. The evolutionary history of vertebrate RNA viruses. Nature. 2018 Apr 4. doi: 10.1038/s41586-018-0012-7. [Epub ahead of print] PubMed PMID: 29618816.