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EV-E seqs
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Unassigned
  Genus: Enterovirus

Species: Enterovirus E

Serotype: enterovirus E1 (EV-E1)  
5' UTR VP4 VP2 VP3 VP1 2A 2B 2C 3A 3B 3C 3D 3' UTR
Serotype: enterovirus E2 (EV-E2)  
5' UTR VP4 VP2 VP3 VP1 2A 2B 2C 3A 3B 3C 3D 3' UTR
Serotype: enterovirus E3 (EV-E3)  
5' UTR VP4 VP2 VP3 VP1 2A 2B 2C 3A 3B 3C 3D 3' UTR
Serotype: enterovirus E4 (EV-E4)  
5' UTR VP4 VP2 VP3 VP1 2A 2B 2C 3A 3B 3C 3D 3' UTR
Serotype: enterovirus E5* (EV-E5)  
5' UTR VP4 VP2 VP3 VP1 2A 2B 2C 3A 3B 3C 3D 3' UTR

(White areas indicate genes which haven't yet been sequenced completely;
grey areas are where only partial sequences exist)

*, candidate type

References

Virus Strain Host Region

Length

Accession No. Reference Comments

Enterovirus E1 (EV-E1)

EV-E1 VG(5)27* (Northern Ireland/57) Bos taurus CG 7414 D00214 Earle et al., 1988  
EV-E1 Vir 404/03 (Germany) Bos taurus CG 7416 DQ092771 Zell et al., 2006  
EV-E1 LC-R4 (USA); ATCC VR-248 Bos taurus CG 7414 DQ092769 Zell et al., 2006  
EV-E1 BEV-1 (Washington/57) Bos taurus 5'NCR(p) 385 AJ250671 Lin et al., 2000  
CG(p) 7379 n/a Knowles et al., unpub.  
EV-E1 D 8/01 (Germany) Bos taurus 5'UTR+P1+2A(p) 3419 DQ092782 Zell et al., 2006  
3C(p)+3D 1759 DQ092783 Zell et al., 2006  
EV-E1 E 6-82 (Germany) Bos taurus 5'UTR+P1+2A(p) 3423 DQ092776 Zell et al., 2006  
3C(p)+3D 1607 DQ092777 Zell et al., 2006  
EV-E1 VD 2860/1-99 Bos taurus 5'UTR+P1+2A(p) 3421 DQ092774 Zell et al., 2006  
3C(p)+3D 1595 DQ092775 Zell et al., 2006  
EV-E1 D 58/96-V2130 (Germany) Bos taurus 5'UTR+P1+2A(p) 3412 DQ092772 Zell et al., 2006  
3C(p)+3D 1691 DQ092773 Zell et al., 2006  
EV-E1 BDEV/USA Tursiops truncatus
(bottlenose dolphin)
VP4(p) to 2A(p) 2613 EU886967 Nollens et al., 2009  
EV-E1 M63 (Worcestershire, England, 1960) Bos taurus CG(p) 7379 n/a Knowles et al., unpub.  
EV-E1? 82Sh2R (India, 1982) Ovis aries 5'NCR(p)

393

AJ250674

Lin et al., unpub.  
EV-E1 82Sh5R (India, 1982) Ovis aries CG(p) 7383 n/a Knowles et al., unpub.  
EV-E1 BAN/2008/709010 Macaca mulatta
(Rhesus macaque)
VP1(p) 252 JX538126 Oberste et al., 2013  
EV-E1 bo/US/PA12-24791/2012 bovine CG 7411 KC667561 Koster and Killian, unpub.  
EV-E1 bo/PD2017 (Italy/2017) Bos taurus CG(p) 7319 MG571548 Zaccaria et al., unpub.  
EV-E1 THAI/B1029/2016 cattle P1+2A(p) 2773 MH894628 Income et al., 2018  
EV-E1 THAI/B1139/2016 cattle P1+2A(p) 2775 MH894629 Income et al., 2018
EV-E1 THAI/B1079/2016 cattle P1+2A(p) 2785 MH894632 Income et al., 2018  
EV-E1 THAI/B1121/2016 cattle P1+2A(p) 2761 MH894633 Income et al., 2018  
EV-E1 B1-TR2016 cattle VP3(p)+VP1(p) 884 MG702506 Coskun & Alkan, unpub.  
EV-E1 114-TR2016
cattle VP3(p)+VP1(p) 884 MG702507 Coskun & Alkan, unpub.  
EV-E1 BOZ-TR2016
cattle VP3(p)+VP1(p) 884 MG702508 Coskun & Alkan, unpub.  
EV-E1 M2-TR2016
cattle VP3(p)+VP1(p) 884 MG702509 Coskun & Alkan, unpub.  
EV-E1 M1-TR2016
cattle VP3(p)+VP1(p) 884 MG702510 Coskun & Alkan, unpub.  
EV-E1 B6-TR2016
cattle VP3(p)+VP1(p) 884 MG702511 Coskun & Alkan, unpub.  
EV-E1 K2-TR2016 cattle VP3(p)+VP1(p) 884 MG702512 Coskun & Alkan, unpub.  
EV-E1 V251/GER/2019 Bos taurus CG 7387 MT019688 B. Hoffmann, unpub.  
               

Enterovirus E2 (EV-E2)

EV-E2 BEV-165* (M4) (Washington/57) Bos taurus CG 7407 N/A McIlhatton et al., 1993  
EV-E2 PS 42; ATCC VR-758 Bos taurus CG 7412 DQ092792 Zell et al., 2006  
EV-E2 PS 83; ATCC VR-757 Bos taurus CG 7413 DQ092793 Zell et al., 2006  
EV-E2 SD 1182 II (Germany) Bos taurus 5'UTR+P1+2A(p) 3414 DQ092784 Zell et al., 2006  
3C(p)+3D 1520 DQ092785 Zell et al., 2006  
EV-E2 D 14/1/96 (Germany) Bos taurus 5'UTR+P1+2A(p) 3414 DQ092780 Zell et al., 2006  
3C(p)+3D 1881 DQ092781 Zell et al., 2006  
EV-E2 56/59/1 (Germany) Bos taurus 5'UTR+P1+2A(p) 3418 DQ092778 Zell et al., 2006  
3C(p)+3D 1559 DQ092779 Zell et al., 2006  
EV-E2 K2577 (Australia) Bos taurus CG 7405 AF123432 McCarthy et al., 1999  
EV-E2 SL305 (Australia) Bos taurus CG 7410 AF123433 McCarthy et al., 1999  
EV-E2 D 3/98 (Germany) Bos taurus 5'UTR+P1+2A(p) 3404 DQ092790 Zell et al., 2006  
3D 1457 DQ092791 Zell et al., 2006  
EV-E2 M134a (Great Britain) Bos taurus CG(p) 6557 n/a Knowles et al., unpub.  
EV-E2 M153 (Hertfordshire, England, 1961) Bos taurus CG 7411 n/a Knowles et al., unpub.  
EV-E2 T10 (Devon, England, 1960) Bos taurus CG(p) 7376 n/a Knowles et al., unpub.  
EV-E2 M6 (Gloucestershire, England, 1960) Bos taurus CG(p) 7379 n/a Knowles et al., unpub.  
EV-E2 HLJ-3531/2013 Bos taurus VP1 840 KJ956699 Zhang et al., 2014  
EV-E2 IS1/Bos taurus/JPN/1990 Bos taurus CG 7413 LC150009 Tsuchiaka et al., 2017  
EV-E2 BJ101/China/2015 Bos taurus CG 7409 MG650158 Zhang et al., unpub.  
EV-E2 EV/NGR/2017 (Nigeria) environmental CG(p) 7368 MH719217 Faleye et al., unpub.  
EV-E2 NGR/2018/Nigeria waste water CG(p) 7344 MT542698 Faleye et al., unpub.  
EV-E2 THAI/B2005/2016 cattle P1+2A(p) 2790 MH894630 Income et al., 2018  
EV-E2 THAI/B2008/2016 cattle P1+2A(p) 2779 MH894631 Income et al., 2018  
EV-E2 K38-TR2016 cattle VP3(p)+VP1(p) 884 MG702503 Coskun & Alkan, unpub.  
EV-E2 GX1901/China/2019 Bos taurus CG 7408 MN607030 Wu et al., unpub.  
EV-E2 GX1902/China/2019 Bos taurus CG 7405 MN607031 Wu et al., unpub.  
               

Enterovirus E3 (EV-E3)

EV-E3 D 14/3/96* (Germany) Bos taurus 5'UTR+P1+2A(p) 3416 DQ092786 Zell et al., 2006  
3C(p)+3D+3'UTR 1892 DQ092787 Zell et al., 2006  
EV-E3 HY12/China/2012 Bos taurus CG 7416 KF748290 Zhu et al., 2014  
EV-E3 5741-TR2016 cattle VP3(p)+VP1(p) 884 MG702504 Coskun & Alkan, unpub.  
EV-E3 3065-TR2016 cattle VP3(p)+VP1(p) 884 MG702505 Coskun & Alkan, unpub.  
               

Enterovirus E4 (EV-E4)

EV-E4 PAK-NIH-21E5* (Karachi, 2009) sewage 5'UTR(p) 183 JQ690748 Shaukat et al., 2012  
VP1 840 JQ690741 Shaukat et al., 2012  
EV-E4 PAK-NIH-48E3 (Quetta, 2011) sewage 5'UTR(p) 183 JQ690749 Shaukat et al., 2012  
VP1 840 JQ690742 Shaukat et al., 2012  
EV-E4 PAK-NIH-59E1 (Lahore, 2010) sewage 5'UTR(p) 183 JQ690750 Shaukat et al., 2012  
VP1 840 JQ690743 Shaukat et al., 2012  
EV-E4 PAK-NIH-67E2 (Lahore, 2010) sewage 5'UTR(p) 183 JQ690751 Shaukat et al., 2012  
VP1 840 JQ690744 Shaukat et al., 2012
EV-E4 PAK-NIH-68E2 (Karachi, 2010) sewage 5'UTR(p) 183 JQ690752 Shaukat et al., 2012  
VP1 840 JQ690745 Shaukat et al., 2012  
EV-E4 PAK-NIH-92E1 (Karachi, 2010) sewage 5'UTR(p) 183 JQ690753 Shaukat et al., 2012  
VP1 840 JQ690746 Shaukat et al., 2012  
EV-E4 PAK-NIH-123E1 (Karachi, 2010) sewage 5'UTR(p) 183 JQ690754 Shaukat et al., 2012  
VP1 840 JQ690747 Shaukat et al., 2012
               

Enterovirus E5? (EV-E5?) (Candidate new type?) - very different in VP1

EV-E5? MexKSU/5/Mexico/2015 Bos taurus CG 7451 KU172420 Mitra et al., 2016  
EV-E5? JS20-1/China/2020 Bos taurus CG(p) 7380 MW579538 Ji et al., unpub.  
EV-E5? GX20-1/China/ Bos taurus CG(p) 7322 MW477470 Ji et al., unpub.  
               

Enterovirus E? (EV-E?)

EV-E? MZ468 Bos taurus 3D+3'UTR 1454 D84065 Hamada et al., 1998  
EV-E? 66/27 (Australia) Bos taurus 5'NCR(p)+VP4(p) ? ? McCarthy et al., 1999  
EV-E? BOT/209/67 (Botswana, 1967) Bos taurus 5'NCR(p) 386 AJ250673 Lin et al., unpub.  
               
CG, complete genome
(p), partial gene sequence
*, prototype strain

References

Earle JA, Skuce RA, Fleming CS, Hoey EM, Martin SJ. The complete nucleotide sequence of a bovine enterovirus. J Gen Virol. 1988 Feb;69 ( Pt 2):253-63. doi: 10.1099/0022-1317-69-2-253. PMID: 2828511.

Hamada N, Masunaga K, Ohtsu Y, Kato H, Tsuji K, Maeda H, Shingu M, Toyoda T. Nucleotide sequence of the gene encoding the RNA polymerase and the 3' non-coding region of a bovine enterovirus Japanese isolate: rapid synonymous substitutions between European and Japanese strains. Arch Virol. 1998;143(4):815-21. doi: 10.1007/s007050050333. PMID: 9638151.

Income N, Kosoltanapiwat N, Taksinoros S, Leaungwutiwong P, Maneekan P, Chavez IF. Molecular identification of enteroviruses from cattle and goat feces and environment in Thailand. Appl Environ Microbiol. 2018 Dec 14. pii: AEM.02420-18. doi: 10.1128/AEM.02420-18. [Epub ahead of print] PubMed PMID: 30552188.

McCarthy FM, Smith GA, Mattick JS. Molecular characterisation of Australian bovine enteroviruses. Vet Microbiol. 1999 Aug 16;68(1-2):71-81. doi: 10.1016/s0378-1135(99)00062-0. PMID: 10501163.

Mitra N, Cernicchiaro N, Torres S, Li F, Hause BM. Metagenomic characterization of the virome associated with bovine respiratory disease in feedlot cattle identified novel viruses and suggests an etiologic role for influenza D virus. J Gen Virol. 2016 Aug;97(8):1771-1784. doi: 10.1099/jgv.0.000492. Epub 2016 May 5. PMID: 27154756; PMCID: PMC5772826.

Nollens HH, Rivera R, Palacios G, Wellehan JF, Saliki JT, Caseltine SL, Smith CR, Jensen ED, Hui J, Lipkin WI, Yochem PK, Wells RS, St Leger J, Venn-Watson S. New recognition of Enterovirus infections in bottlenose dolphins (Tursiops truncatus). Vet Microbiol. 2009 Oct 20;139(1-2):170-5. doi: 10.1016/j.vetmic.2009.05.010. Epub 2009 Jun 6. PMID: 19581059; PMCID: PMC4310689.

Oberste MS, Feeroz MM, Maher K, Nix WA, Engel GA, Hasan KM, Begum S, Oh G, Chowdhury AH, Pallansch MA, Jones-Engel L. Characterizing the picornavirus landscape among synanthropic nonhuman primates in Bangladesh, 2007 to 2008. J Virol. 2013 Jan;87(1):558-71. doi: 10.1128/JVI.00837-12. Epub 2012 Oct 24. PMID: 23097448; PMCID: PMC3536389.

Shaukat S, Angez M, Alam MM, Sharif S, Khurshid A, Malik F, Rana MS, Mahmood T, Zaidi SS. Molecular identification and characterization of a new type of bovine enterovirus. Appl Environ Microbiol. 2012 Jun;78(12):4497-500. doi: 10.1128/AEM.00109-12. Epub 2012 Apr 6. Erratum in: Appl Environ Microbiol. 2012 Aug;78(16):5972. PMID: 22492440; PMCID: PMC3370518.

Tsuchiaka, S., Rahpaya, S.S., Otomaru, K., Aoki, H., Kishimoto, M., Naoi, Y., Omatsu, T., Sano, K., Okazaki-Terashima, S., Katayama, Y., Oba, M., Nagai, M. and Mizutani, T. (2017). Identification of a novel bovine enterovirus possessing highly divergent amino acid sequences in capsid protein. BMC Microbiol. 17: 18.

Zell R, Krumbholz A, Dauber M, Hoey E, Wutzler P. Molecular-based reclassification of the bovine enteroviruses. J Gen Virol. 2006 Feb;87(Pt 2):375-385. doi: 10.1099/vir.0.81298-0. PMID: 16432025.

 

 
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