A tick-borne infection occurring in the river valleys of
Kazakhstan. SDF virus was first isolated from the blood of a patient in the
summer of 1973. The virus has also been isolated from Hyalomma asiaticum
ticks in enzootic areas and from Dermacentor daghestanicus ticks. All
documented cases in humans give a history of tick bite.
The onset of illness is abrupt with temperatures of 39-40
°C, shivering, weakness, headache and an extensive roseolar-petechial rash
mainly on the extremities, chest and abdomen.
The Kaz-3 strain was studied by electron
microscopy revealing featureless 25-27 nm virions typical of picornaviruses.
Serologically related to both
Sikhote-Alyn virus and mengovirus (EMCV) by complement fixation but all three are distinct
Karimov, S.K., Lvov, D.K. and Kiryushchenko, T.V. (1989).
Syrdarya Valley fever, a new virus disease in Kazakhstan. In: Arboviruses and
Arboviral Infections. Abstracts book, ed. by D.K. Lvov. from "An International
Symposium on Arboviruses and Arboviral Infections", Moscow, U.S.S.R., October
Karimov, S.K., Lvov, D.K. and Kiryushchenko, T.V. (1990). Syrdarya Valley fever, a new virus disease in Kazakhstan. Arch. Virol., Suppl.
L'vov, D.K., Karimov, S.K., Kiriushchenko, T.V., Chun-Siun,
F., Skvortsova, T.M. (1984). [Isolation of the virus of Syr-Darya Valley
fever] Vopr Virusol. 29: 553-558 (In Russian).
Lvov, D.K. (1994). Arboviral zoonoses of Northern Eurasia
(Eastern Europe and the Commonwealth of Independent States). In: Handbook of
Zoonoses, 2nd Edition, Section B: Viral, Ed. G.W. Beran, CRC Press Inc., Boca
Raton, p. 237-260.
Lvov, D.K., Alkhovsky, S.V., Shchelkanov, M. Yu.,
Shchetinin, A.M., Deryabin, P.G., Gitelman, A.K., Aristova, V.A. and Botikov,
A.G. (2014). Genetic characterization of the Syr-Darya valley fever virus
(SDVFV) (Picornaviridae, Cardiovirus) isolated from the
blood of the patients and ticks Hyalomma as. asiaticum (Hyalomminae),
Dermacentor daghestanicus (Rhipicephalinae) (Ixodidae) and (Argasidae)
in Kazakhstan and Turkmenistan. Vopr Virusol. 59:
15-19. In Russian.