Rabovirus A

The
Picornavirus
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Rabovirus A is one of four species in the genus Rabovirus.

The near-complete genome of a rat picornavirus from the USA has been determined (Firth et al., 2014). Almost simultaneously, two genomic fragments of a rat picornavirus were identified in 12 Rattus norvegicus in Berlin, Germany (Sachsenröder et al., 2014). Later the complete genome of the now-named rabovirus (RaBoV) was published (Ng et al., 2015). The sequences were most closely related to sapelo- and enteroviruses. Both genome sequences contain an type II-like IRES. Five genetic types RaBoV-A1 to RaBoV-A25 have been described, based on their VP1 sequences.

Genome organisation:

VPg+5’UTR^IRES-II[L/1A-1B-1C-1D/2A-2B-2C/3A-3B^VPg-3C^pro-3D^pol]3’UTR-poly(A)

References

Firth, C., Bhat, M., Firth, M.A., Williams, S.H., Frye, M.J., Simmonds, P., Conte, J.M., Ng, J., Garcia, J., Bhuva, N.P., Lee, B., Che, X., Quan, P.L. and Lipkin, W.I. (2014). Detection of zoonotic pathogens and characterization of novel viruses carried by commensal Rattus norvegicus in New York City. mBio 5(5). pii: e01933-14.

Ng, T.F., Sachsenröder, J., Reuter, G., Knowles, N.J., Delwart, E. and Johne, R. (2015). Rabovirus: a proposed new picornavirus genus that is phylogenetically basal to enteroviruses and sapeloviruses. Arch. Virol. 160: 2569-2575.

Sachsenröder, J., Braun, A., Machnowska, P., Ng, T.F., Deng, X., Guenther, S., Bernstein, S., Ulrich, R.G., Delwart, E. and Johne, R. (2014). Metagenomic identification of novel enteric viruses in urban wild rats and genome characterization of a group A rotavirus. J. Gen. Virol. 95: 2734-2747.