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Cadicivirus A is the type (and only) species in the genus Dicipivirus. It contains a novel small RNA virus, known as canine picodicistrovirus, which has recently been found in dogs (Woo et al., 2012). The genome sequence appears to be most closely related to the picornaviruses and to have a similar genome organization, except that the P1 and P2/P3 regions are encoded in two ORFs separated by an intergenic region containing an IRES. It is the first naturally occurring dicisronic picornavirus to be described. A functional dicistronic poliovirus had previously been artificially constructed (Molla et al., 1992).

Origin of name: Canine dicistronic picornavirus.

Genome organisation:

VPg+5'UTR^IRES[1A-1B-1C-1D]IGR^IRES[2A-2B-2C/3A-3B^VPg-3C^pro-3D^pol]3'UTR-poly(A)

IGR, intergenic region
IRES, internal ribosome entry site
[] ORF
/ primary cleavage

References

Molla, A., Jang, S.K., Paul, A.V., Reuer, Q. and Wimmer, E. (1992). Cardioviral internal ribosomal entry site is functional in a genetically engineered dicistronic poliovirus. Nature.  356(6366): 255-257.

Woo, P.C., Lau, S.K., Choi, G.K., Huang, Y., Teng, J.L., Tsoi, H.W., Tse, H., Yeung, M.L., Chan, K.H., Jin, D.Y. and Yuen, K.Y. (2012). Natural occurrence and characterization of two internal ribosome entry site elements in a novel virus, canine picodicistrovirus, in the picornavirus-like superfamily. J. Virol. 86: 2797-2808. Epub 2011 Dec 28.