Rosavirus A

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Picornavirus
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Rosavirus A is a species in the genus Rosavirus. The name rosavirus is derived from rodent stool-associated picornavirus. The species is comprised of two types.

Type 1: A novel picornavirus (designation M-7) found in the faeces of a canyon mouse (Peromyscus crinitus) in the USA in 2010 (JF973686; Phan et al., 2011, 2013).

Type 2: A second rosavirus genotype has been discovered in children in the Gambia (Lim et al., 2014).

Genome organisation:

VPg+5’UTR^IRES-II[1A-1B-1C-1D/2A^H-Box/NC-2B-2C/3A-3B^VPg-3C^pro-3D^pol]3’UTR-poly(A)

References

Lim, E.S., Cao, S., Holtz, L.R., Antonio, M., Stine, O.C. and Wang, D. (2014). Discovery of rosavirus 2, a novel variant of a rodent-associated picornavirus, in children from The Gambia. Virology 454-455: 25-33.

Phan, T.G., Kapusinszky, B., Wang, C., Rose, R.K., Lipton, H.L. and Delwart, E.L. (2011). The fecal viral flora of wild rodents. PLoS Pathog 7(9): e1002218. doi:10.1371/journal.ppat.1002218.

Phan, T.G., Vo, N.P., Simmonds, P., Samayoa, E., Naccache, S., Chiu, C.Y. and Delwart, E. (2013). Rosavirus: the prototype of a proposed new genus of the Picornaviridae family. Virus Genes. 47: 556-558.