Salivirus A

Child level

Salivirus seqs

Same level

  Salivirus A is the type (and only) species of the genus Salivirus.

Two closely related human kobu-like viruses have been reported:

Salivirus, NG-J1 (Li et al., 2009; GQ179640);

Human klassevirus 1, isolate 02394-01 (Greninger et al., 2009; GQ184145);

Human klassevirus 1 (Holtz et al., 2009; GQ253930).

Recently, the nearly complete genome sequence (6397 nt) of a candidate second salivirus type has been determined from a sewage sample from Bangkok, Thailand (Ng et al., 2012; SaliV-SewBKK; JQ898343). A closely related genome sequence has been found in a child in China (Yu & Duan, unpub.; KM023140).

Genome organisation:


Host range

Saliviruses have been detected in humans and chimpanzees.

3A polypeptide

Recently, Greninger et al. (2012) have report that the N-terminal glycines of Aichi virus, bovine kobuvirus and human salivirus (klassevirus) are myristoylated despite not having a canonical myristoylation motif (GxxxT/S).


Greninger, A.L., Runckel, C., Chiu, C.Y., Haggerty, T., Parsonnet, J., Ganem, D. and DeRisi, J.L. (2009). The complete genome of klassevirus - a novel picornavirus in pediatric stool. Virology Journal 6: 82 doi:10.1186/1743-422X-6-82.

Greninger, A.L., Knudsen, G.M., Betegon, M., Burlingame, A.L. and Derisi, J.L. (2012). The 3A protein from multiple picornaviruses utilizes the golgi adaptor protein ACBD3 to recruit PI4KIIIβ. J Virol. 86: 3605-3616. Epub 2012 Jan 18.

Holtz, L.R., Finkbeiner, S.R., Zhao, G., Kirkwood, C.D., Girones, R., Pipas, J.M. and Wang, D. (2009). Klassevirus 1, a previously undescribed member of the family Picornaviridae, is globally widespread. Virology Journal 2009, 6: 86 doi:10.1186/1743-422X-6-86.

Li, L., Victoria, J., Kapoor, A., Blinkova, O., Wang, C., Babrzadeh, F., Mason, C.J., Pandey, P., Triki, H., Bahri, O., Oderinde, B.S., Baba, M.M., Bukbuk, D.N., Besser, J.M., Bartkus, J.M. and Delwart, E.L. (2009). A novel picornavirus associated with gastroenteritis. J Virol. 83: 12002-12006. Epub 2009 Sep 16. doi:10.1128/JVI.01241-09.

Ng, T.F., Marine, R., Wang, C., Simmonds, P., Kapusinszky, B., Bodhidatta, L., Oderinde, B.S., Wommack, K.E. and Delwart, E. (2012). High variety of known and new RNA and DNA viruses of diverse origins in untreated sewage. J. Virol. 2012 Aug 29. [Epub ahead of print]

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