Avisivirus A

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Picornavirus
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Avisivirus A is a species in the genus Avisivirus. It comprises of a novel picornavirus discovered in Turkeys (Meleagris gallopavo) in Hungary and named turkey avisivirus 1 (TuAsV-1) (from avihepatovirus sister-clade). It is most closely related to, but distinct from, Duck hepatitis A virus (genus Avihepatovirus) (Boros et al., 2013). Uniquely, TuAsV-1 has four 2A-like motifs (but probably only three 2A polypeptides).

A second genome sequence of an avisivirus in turkeys in the USA has been determined (Ng et al., 2013); the two genomes share 81% nt identity. Their VP1 sequences share 77% nt identity and 87% aa identity. However, the two polyproteins differ in that the polypeptide containing the second 2A motif (76 aa) is missing in the American virus.

The 5' UTR of avisiviruses is predicted to contain a type II internal ribosome entry site (IRES) (Boros et al., 2013).

Genome organisation

VPg+5'UTR^IRES-II[1AB-1C-1D?2A^npgp/(2A^npgp)/2A^AIG1-like-2A^H-Box/NC-2B-2C/3A-3B^VPg-3C^pro-3D^pol]3'UTR-poly(A)

?, indicates that it is unclear if a cleavage occurs between 1D and the short 2A-like peptide.
(), indicates that this predicted polypeptide is not present in all the avisiviruses.

References

Boros, Á., Nemes, C., Pankovics, P., Kapusinszky, B., Delwart, E. and Reuter, G. (2013). Genetic characterization of a novel picornavirus in turkeys (Meleagris gallopavo) distinct from turkey galliviruses and megriviruses and distantly related to the members of the genus Avihepatovirus. J. Gen. Virol. 94: 1496-1509. [Epub ahead of print 2013 Apr 4].

Ng, T.F.F., Cheung, A.K., Wong, W., Lager, K.M., Kondov, N.O., Cha, Y., Murphy, D.A., Pogranichniy, R.M. and Delwart, E. (2013). Divergent picornavirus from a turkey with gastrointestinal disease. Genome Announcements 1 (3), e00134-13.