The
Picornavirus
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| Pasivirus A is a species in
the genus Pasivirus. Sauvage et al. (2012) recently described the molecular detection of a new picornavirus in healthy pigs in France. They named it swine pasivirus; “Pasivirus” for “Parecho sister-clade virus”, with the “Swine pasivirus 1” (SPaV1) proposed as the type species. More details will follow later... A second swine pasivirus genome sequence (from pig faeces) was submitted to GenBank on 15-AUG-2012 (JX491648; Yu et al., 2013). The two genomes share 80% nt identity. Their VP1 nt and aa sequences differ by about 24.5% and 16.5%, respectively, therefore they may represent two distinct types. A third swine pasivirus genome sequence has been determined and has been predicted to contain a type IV IRES (KM259923; Boros et al., 2015). The three viruses share 72-75% nt identity and 74-77% aa identity in their VP1 regions, suggesting they belong to three distinct (geno)types, PaV-A1, PaV-A2 and PaV-3. Genome organization: VPg+5'UTRIRES-IV[1AB-1C-1D-2A1npgp/2A2-2B-2C/3A-3BVPg-3Cpro-3Dpol]3'UTR-poly(A) References Boros, Á., Fenyvesi, H., Pankovics, P., Biró, H., Phan, T.G., Delwart, E. and Reuter, G. (2015). Secondary structure analysis of swine pasivirus (family Picornaviridae) RNA reveals a type-IV IRES and a parechovirus-like 3' UTR organization. Arch. Virol. 160: 1363-1366. Sauvage, V., Ar Gouilh, M., Cheval, J., Muth, E., Pariente, K., Burguiere, A., Caro, V., Manuguerra, J.C. and Eloit, M. (2012). A member of a new Picornaviridae genus is shed in pig feces. J. Virol. 86: 10036-10046. Epub 2012 Jul 11. Yu, J.M., Li, X.Y., Ao, Y.Y., Li, L.L., Liu, N., Li, J.S. and Duan, Z.J. (2013). Identification of a novel picornavirus in healthy piglets and seroepidemiological evidence of its presence in humans. PLoS One. 8(8):e70137. |