The
Picornavirus
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Child level |
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Same level |
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Genera |
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| The genus Cosavirus
consists of five species Cosavirus
A,
Cosavirus B,
Cosavirus D,
Cosavirus E
and Cosavirus F.
The candidate species, 'Cosavirus C', remains unclassified due to a lack of
full genome sequence data. Cosaviruses (formerly called Dekaviruses) have been identified in the stools of south Asian children (Kapoor et al., 2008; Holtz et al., 2008; Kapusinszky et al., 2012). Cosaviruses are most closely related to members of the Cardiovirus and Senecavirus genera, but they lack a leader polypeptide. They possess an 2A NPG¯P motif, which may or may not be cleaved from VP1. An unusually long (1,164 nt) 5' UTR contains a type II IRES. Derivation of name: Cosavirus is from common stool-associated picornavirus. Genome organisation: VPg+5'UTRIRES-II[1A-1B-1C-1D-2Anpgp/2B-2C/3A-3BVPg-3Cpro-3Dpol]3'UTR-poly(A) Search of Cosavirus sequences on GenBank References Holtz, L.R., Finkbeiner, S.R., Kirkwood, C.D. and Wang, D. (2008). Identification of a novel picornavirus related to cosaviruses in a child with acute diarrhea. Virology Journal 5: 159; doi:10.1186/1743-422X-5-159. Kapoor, A., Victoria, J., Simmonds, P., Slikas, E., Chieochansin, T., Naeem, A., Shaukat, S., Sharif, S., Masroor Alam, M., Angez, M., Wang, C., Shafer, R.W., Zaidi, S. and Delwart, E. (2008). A highly prevalent and genetically diversified Picornaviridae genus in South Asian children. Proc. Natl. Aad. Sci., USA 105: 20482-20487. doi 10.1073 pnas.0807979105. Kapusinszky, B., Phan, T.G., Kapoor, A. and Delwart, E. (2012). Genetic diversity of the genus Cosavirus in the family Picornaviridae: a new species, recombination, and 26 new genotypes. PLoS One. 7(5):e36685. Epub 2012 May 16. |