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AiV-B1 seqs
Discovery of BKV

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Unassigned
  Genus: Kobuvirus

Species: Aichivirus B

Type: aichivirus B1 (AiV-B1)  
5' UTR L VP0 VP3 VP1 2A 2B 2C 3A 3B 3C 3D 3' UTR
     

(White areas indicate genes which haven't yet been sequenced completely; grey areas are where only partial sequences exist)

Virus Strain Region

Length

Accession No. Reference Comments

Aichivirus B1 (AiV-B1) aka bovine kobuvirus 1 (BKV)

AiV-B1 bov/U-1/Japan CG 8374 AB084788 Yamashita et al., 2003  
AiV-B1 bov/BV228/2008/BEL VP3(p)+VP1(p) 690 FJ946860 Mauroy et al., 2009  
AiV-B1 bov/H5/China/2010 VP1 801 KF728711 Chang et al., 2013  
AiV-B1 bov/H7/China/2010 VP1 801 KF728712 Chang et al., 2013  
AiV-B1 bov/H8/China/2010 VP1 801 KF728713 Chang et al., 2013  
AiV-B1 bov/H9/China/2010 VP1 801 KF728714 Chang et al., 2013  
AiV-B1 bov/H13/China/2010 VP1 801 KF728715 Chang et al., 2013  
AiV-B1 bov/H16/China/2010 VP1 801 KF728716 Chang et al., 2013  
AiV-B1 bov/H18/China/2010 VP1 801 KF728717 Chang et al., 2013  
AiV-B1 bov/H19/China/2010 VP1 801 KF728718 Chang et al., 2013  
AiV-B1 bov/H23/China/2011 VP1 801 KF728719 Chang et al., 2013  
AiV-B1 bov/H29/China/2011 VP1 801 KF728720 Chang et al., 2013  
AiV-B1 bov/GN1155/China/2010 VP1 801 KF728721 Chang et al., 2013  
AiV-B1 bov/X3-4/China/2007 VP1 801 KF728722 Chang et al., 2013  
AiV-B1 bov/X3-14/China/2007 VP1 801 KF728723 Chang et al., 2013  
AiV-B1 bov/X3-23/China/2007 VP1 801 KF728724 Chang et al., 2013  
AiV-B1 bov/X3-77/China/2007 VP1 801 KF728725 Chang et al., 2013  
AiV-B1 bov/X3-78/China/2007 VP1 801 KF728726 Chang et al., 2013  
AiV-B1 bov/X3-143/China/2007 VP1 801 KF728727 Chang et al., 2013
AiV-B1 bov/SC1/UK/2013 CG(p) 8293 KT003671 Gregory et al., unpub.  
AiV-B1 bov/EGY-1/2014 CG(p) 8319 KY407744 Mohamed et al., 2018  
AiV-B1 bov/IL35164/USA/2019 CG(p) 8337 MN336260 Wang et al., 2020  
AiV-B1 bov/1043507/CAN/2020 CG(p) 8329 MW605074 Savard et al., 2021  
AiV-B1 bov/CN/HB-SJZ/2021 CG(p) 8376 MZ603734 Wu et al., 2021  
AiV-B1 bov/CHZ/China/2018 CG(p) 7907 MK080265 L,H., T,C. and Y,H.  
             

Unassigned bovine-like kobuviruses in cattle

BKV-? K-3/Japan 3D(p) 591 AB097152 Yamashita et al., 2003  
BKV-? K-4/Japan 3D(p) 591 AB097153 Yamashita et al., 2003  
BKV-? K-6/Japan 3D(p) 591 AB097154 Yamashita et al., 2003  
BKV-? K-35/Japan 3D(p) 591 AB097155 Yamashita et al., 2003  
BKV-? K-36/Japan 3D(p) 591 AB097156 Yamashita et al., 2003  
BKV-? K-38/Japan 3D(p) 591 AB097157 Yamashita et al., 2003  
BKV-? K-44/Japan 3D(p) 591 AB097158 Yamashita et al., 2003  
BKV-? K-49/Japan 3D(p) 591 AB097159 Yamashita et al., 2003  
BKV-? K-55/Japan 3D(p) 591 AB097160 Yamashita et al., 2003  
BKV-? K-60/Japan 3D(p) 591 AB097161 Yamashita et al., 2003  
BKV-? N-2/Japan 3D(p) 591 AB097162 Yamashita et al., 2003  
BKV-? N-5/Japan 3D(p) 591 AB097163 Yamashita et al., 2003  
BKV-? CMB02/Thailand 3D(p) 591 EF659450 Khamrin et al., 2008  
BKV-? CMB03/Thailand 3D(p) 591 EF659451 Khamrin et al., 2008  
BKV-? CMB06/Thailand 3D(p) 591 EF659452 Khamrin et al., 2008  
BKV-? CMB07/Thailand 3D(p) 591 EF659453 Khamrin et al., 2008  
BKV-? CMB10/Thailand 3D(p) 591 EF659454 Khamrin et al., 2008  
BKV-? CMB11/Thailand 3D(p) 591 EF659455 Khamrin et al., 2008  
BKV-? Aba-Z20/2002/Hungary 3D(p) 862 FJ225406 Reuter & Egyed, 2009  
BKV-? BV250/2008/BEL 3D(p) 612 FJ946861 Mauroy et al., 2009  
BKV-? BV253/2008/BEL 3D(p) 806 FJ946862 Mauroy et al., 2009  
BKV-? cattle/08KB680/KOR/2008 3D(p) 454 JQ026109 Lee et al., 2012  
BKV-? bovine/NLD71/2007/Netherlands 3D(p) 215 HQ877629 Barry et al., 2011  
BKV-? bovine/NLD74/2007/Netherlands 3D(p) 216 HQ877630 Barry et al., 2011  
BKV-? 8TE-11-ITA 3D(p) 428 JQ900629 Di Martino et al., 2012  
BKV-? 21TE-11-ITA 3D(p) 576 JQ900630 Di Martino et al., 2012  
BKV-? 81TE-11-ITA 3D(p) 379 JQ900631 Di Martino et al., 2012  
BKV-? 109TE-11-ITA 3D(p) 583 JQ900632 Di Martino et al., 2012  
BKV-? 118TE-11-ITA 3D(p) 574 JQ900633 Di Martino et al., 2012  
BKV-? 119TE-11-ITA 3D(p) 582 JQ900634 Di Martino et al., 2012  
BKV-? 104TE-11 ITA 3D(p) 591 JX070084 Di Martino et al., 2012  
BKV-? BRA02/2012 3D(p) 207 KJ402443 Ribeiro et al., unpub.  
             
CG = complete genome
(p) = partial gene sequence

References

Barry, A.F., Ribeiro, J., Alfieri, A.F., van der Poel, W.H. and Alfieri, A.A. (2011). First detection of kobuvirus in farm animals in Brazil and the Netherlands. Infect. Genet. Evol. 11: 1811-1814.

Chang, J., Wang, Q., Wang, F., Jiang, Z., Liu, Y. and Yu, L. (2013). Prevalence and genetic diversity of bovine kobuvirus in China. Arch. Virol., in press.

Di Martino, B., Di Profio, F., Di Felice, E., Ceci, C., Pistilli, M.G. and Marsilio, F. (2012). Molecular detection of bovine kobuviruses in Italy. Arch. Virol., in press.

Khamrin, P., Maneekarn, N., Peerakome, S., Okitsu, S., Mizuguchi, M. and Ushijama, H. (2008). Bovine kobuviruses from cattle with diarrhea. Emerg Infect Dis. 14: 985–986.

Khamrin P, Maneekarn N, Hidaka S, Kishikawa S, Ushijima K, Okitsu S, Ushijima H. (2010). Molecular detection of kobuvirus sequences in stool samples collected from healthy pigs in Japan. Infection, Genetics and Evolution 10: 950–954.

Lee, M.H., Jeoung, H.Y., Lim, J.A., Song, J.Y., Song, D.S. and An, D.J. (2012). Kobuvirus in South Korean black goats. Virus Genes 45: 186-189. Epub 2012 Apr 12.

Mauroy, A., Scipioni, A., Mathijs, E., Thys, C. and Thiry, E. (2009). Molecular detection of kobuviruses and recombinant noroviruses in cattle in continental Europe. Arch. Virol. 154: 1841-1845. Epub 2009 Oct 9.

Mohamed, F.F., Mansour, S.M.G, Orabi, A., El-Araby, I.E., Ng, T.F.F., Mor, S.K. and Goyal, S.M. (2018). Detection and genetic characterization of bovine kobuvirus from calves in Egypt. Arch Virol. 2018 Feb 8. doi: 10.1007/s00705-018-3758-1. [Epub ahead of print]

Okitsu, S., Khamrin, P., Thongprachum, A., Hidaka, S., Kongkaew, S., Kongkaew, A., Maneekarn, N., Mizuguchi, M., Hayakawa, S. and Ushijima, H. (2011). Sequence analysis of porcine kobuvirus VP1 region detected in pigs in Japan and Thailand. Virus Genes 44: 253-257. Epub 2011 Nov 23.

Reuter, G. and Egyed L. (2009). Bovine kobuvirus in Europe. Emerg. Infect. Dis. 15: 822-823.

Savard C, Ariel O, Fredrickson R, Wang L, Broes A. Detection and genome characterization of bovine kobuvirus (BKV) in faecal samples from diarrhoeic calves in Quebec, Canada. Transbound Emerg Dis. 2021 Mar 31. doi: 10.1111/tbed.14086. Epub ahead of print. PMID: 33788413.

Wang L, Fredrickson R, Duncan M, Samuelson J, Hsiao SH. Bovine Kobuvirus in Calves with Diarrhea, United States. Emerg Infect Dis. 2020 Jan;26(1):176-178. doi: 10.3201/eid2601.191227. PubMed PMID: 31855534; PubMed Central PMCID: PMC6924891.

Wu Q, Li J, Wang W, Zhou J, Wang D, Fan B, Zhang X, Sun D, Gong G, Suolang S, Li B. Next-Generation Sequencing Reveals Four Novel Viruses Associated with Calf Diarrhea. Viruses. 2021; 13(10):1907. https://doi.org/10.3390/v13101907.

Yamashita, T., Ito, M., Kabashima, Y., Tsuzuki, H., Fujiura, A. and Sakae, K. (2003). Isolation and characterization of a new species of kobuvirus associated with cattle. J. Gen. Virol. 84: 3069-3077.

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