TMEV seqs

Virus	Strain	Region	Length	Accession No.	Reference	Comments
Theiler's murine encephalomyelitis virus (TMEV)
TMEV	GD VII (New York/37)	3C+3D+3' NCR	1924	M14703	Ozden et al., 1986
		CG	8105	M20562	Pevear et al., 1988
		CG	8101	X56019	Law et al., 1990
TMEV	DA (Boston/52)	CG	8093	M20301	Ohara et al., 1988
TMEV	DA (Boston/52)	CG	8120	JX443418	Sorgeloos et al., 2013
TMEV	Da3d-e	CG	8094	KF680264	H.L. Lipton, unpub.	derived from DA strain isolated in 1952; synthetically generated under siRNA pressure on the viral polymerase 3D
TMEV	BeAn 8386 (Brazil/57)	CG	8098	M16020	Pevear et al., 1987
TMEV	M2 (from BeAn 8386)	L+P1	2766	AF030574	Kim et al., 1998	low-pathogenic M2 variant of strain BeAn 8386
TMEV	S2 (variant of BeAn 8386)	CG	8100	DQ401688	Myoung et al., 2007
TMEV	TO4 (New York/37)	5'NCR(p)	534	M80885	Pritchard et al., 1992b
TMEV	TO4 (New York/37)	L+P1	2760	U33045	Michiels et al., 1995
TMEV	TO4 (B15)	5'NCR(p)	521	M80886	Pritchard et al., 1992b
TMEV	TO4 (B15)	CG	8100	EU718732	Liang et al., 2008
TMEV	FA (New York/37)	5'NCR(p)	532	M80883	Pritchard et al., 1992b
TMEV	FA (New York/37)	L+P1	2766	U32924	Michiels et al., 1995
TMEV	TO Yale (1943)	5'NCR(p)	529	M80890	Pritchard et al., 1992b
		L+P1	2766	U33047	Michiels et al., 1995
		CG	8096	EU723238	Liang et al., 2008
TMEV	WW (Philadelphia/77)	5'NCR(p)	534	M80889	Pritchard et al., 1992b
TMEV	WW (Philadelphia/77)	L+P1	2760	U33046	Michiels et al., 1995
TMEV	VL	5'NCR+L(p)	1100	M80887	Pritchard et al., 1992b
TMEV	ASK-1	P1	2649	U20288	Luo et al., unpublished
TMEV	?	5'UTR(p)	58	S61105	Bandyopadhyay et al., 1993
TMEV	MHG*	5'NCR(p)+L(p)	521	M80884	Pritchard et al., 1992b
TMEV	Vie415HTR	CG	8096	EU718733	Liang et al., 2008
TMEV	NIHE (Vietnam, 2007)	CG	8102	HQ652539	Buckwalter et al., 2011
TMEV	SB (USA: 14-Nov-2011)	L-2C	3996	JX185320	Grove et al., 2012	host: Mus musculus
TMEV	SD (USA: 14-Nov-2011)	L-2C	3996	JX185321	Grove et al., 2012	host: Mus musculus
TMEV	Sikhote-Alin P113/Russia/1970	CG	7998	KJ191558	Alkhovsky et al., unpub.	host: Ixodes persulcatus ticks
TMEV	NYC/Manhattan/poolF4/2014	CG(p)	7986	MF416403	Williams et al., 2018	host: Mus musculus

* also known as rat encephalomyelitis virus. CG = complete genome; (p) = partial gene sequence.

References

Alkhovsky, S.V., Shchetinin, A.M., Lvov, D.K. and Shchelkanov, M.Y., unpublished data.

Bandyopadhyay, P.K., Pritchard, A., Jensen, K. and Lipton, H.L. (1993). A three-nucleotide insertion in the H stem-loop of the 5' untranslated region of Theiler's virus attenuates neurovirulence. J. Virol. 67: 3691-3695.

Buckwalter, M.R., Nga, P.T., Gouilh, M.A., Fiette, L., Bureau, J.F., Laird, M.E., Buchrieser, J., Ozden, S., Cheval, J., Eloit, M., Manuguerra, J.C., Gessain, A., Brey, P.T., Fontanet, A. and Albert, M.L. (2011). Identification of a novel neuropathogenic Theiler's murine encephalomyelitis virus. J. Virol. 85: 6893-6905.

Grove, T., Smith, P.C., Booth, C.J. and Compton, S.R. (2012). Are younger mice better bedding sentinels? An assessment of age susceptibility of Swiss Webster mice to MPV and other excluded murine pathogens. J. Am. Assoc. Lab. Anim. Sci., in press.

Kim, B.S., Yauch, R.L., Bahk, Y.Y., Kang, J.A., Dal Canto, M.C. and Hall, C.K. (1998). A spontaneous low-pathogenic variant of Theiler's virus contains an amino acid substitution within the predominant VP1(233-250) T-cell epitope. J. Virol. 72: 1020-1027. Erratum in: J. Virol 1998 72: 6965.

Law, K.M. and Brown, T.D.K. (1990). The complete nucleotide sequence of the GDVII strain of Theiler's murine encephalomyelitis virus (TMEV). Nucl. Acids Res. 18: 6707-6708.

Liang, Z., Manoj Kumar, A.S., Jones, M.S., Knowles, N.J. and Lipton, H.L. (2008). Phylogenetic analysis of the species Theilovirus: emerging murine and human pathogens. Journal of Virology 82: 11545–11554.

Luo, M., Pritchard, A.E. and Lipton, H. The structure of a highly virulent Theiler's murine encephalomyelitis virus (GDVII strain) and implications for determinants of viral persistence. Unpublished. (Pritchard A. E., University Colorado Health Sciences Center, Biochemistry, Biophysics and Genetics, 4200 E. Ninth, Denver, CO 80262, USA)

Michiels, T., Jarousse, N. and Brahic, M. (1995). Analysis of the leader and capsid coding regions of persistent and neurovirulent strains of Theiler's virus. Virology 214: 550-558.

Myoung, J., Hou, W., Kang, B., Lyman, M.A., Kang, J.-A. and Kim, B.S. (2007). The immunodominant CD8+ T cell epitope region of Theiler's virus in resistant C57BL/6 mice is critical for anti-viral immune responses, viral persistence, and binding to the host cells. Virology 360: 159-171.

Ohara, Y., Stein, S., Fu, J., Stillman, L., Klaman, L. and Roos, R.P. (1988). Molecular cloning and sequence determination of DA strain of Theiler's murine encephalomyelitis viruses. Virology 164: 245-255.

Ozden, S., Tangy, F., Chamorro, M. and Brahic, M. (1986). Theiler's virus genome is closely related to that of encephalomyocarditis virus, the prototype cardiovirus. J. Virol. 60: 1163-1165.

Pevear, D.C., Calenoff, M., Rozhon, E. and Lipton, H.L. (1987). Analysis of the complete nucleotide sequence of the picornavirus Theiler's murine encephalomyelitis virus indicates that it is closely related to cardioviruses. J. Virol. 61: 1507-1516.

Pevear, D.C., Borkowski, J., Calenoff, M., Oh, C.K., Ostrowski, B. and Lipton, H.L. (1988). Insights into Theiler's virus neurovirulence based on a genomic comparison of the neurovirulent GDVII and less virulent BeAn strains. Virology 165: 1-12.

Pritchard, A.E., Strom, T., and Lipton, H.L. (1992a). Nucleotide sequence identifies vilyuisk virus as a divergent Theiler's virus. Virology 191: 469-472.

Pritchard, A.E., Calenoff, M.A., Simpson, S., Jensen, K., and Lipton, H.L. (1992b). A single base deletion in the 5' noncoding region of Theiler's virus attenuates neurovirulence. J. Virol. 66: 1951-1958.

Sorgeloos, F., Jha, B.K., Silverman, R.H. and Michiels, T. (2013). Evasion of antiviral innate immunity by Theiler's virus L* protein through direct inhibition of RNase L. PLoS Pathog. 9 (6), E1003474.

Willams, S.H., Che, X., Garcia, J.A., Klena, J.D., Lee, B., Muller, D., Ulrich, W., Corrigan, R.M., Nichol, S., Jain, K. and Lipkin, W.I. (2018). Viral Diversity of House Mice in New York City. MBio 9 (2), e01354-17.

Species: Cardiovirus B

Theiler's murine encephalomyelitis virus (TMEV)

References