Aphthovirus struct.

Foot-and-mouth disease virus (FMDV)
Virus	PDB no.	Description [EMBL accession no.]	Reference
FMDV-O	1BBT	O₁/BFS 1860/UK/67 capsid [protein sequence]	Acharya et al., 1989
	1FOD	O₁/BFS 1860/UK/67 capsid (reduced)	Logan et al., 1993
	N/A	O₁/Kaufbeuren/FRG/66 capsid	Lea et al., 1995
	N/A	O₁/Kaufbeuren/FRG/66 (G67 variant) capsid	Lea et al., 1995
	1QOL	O₁/Kaufbeuren/FRG/66 Leader (Lb) protease	Guarne et al., 1998
	1QMY	O₁/Kaufbeuren/FRG/66 Leader (Lb) protease	Guarne et al., 2000
	1QQP	O₁/BFS 1860/UK/67 capsid complexed with oligosaccharide receptor	Fry et al., 1999
	5AC9	O	Kotecha et al., 2015
	5DDJ	O1/Manisa/TUR/69-S2093Y empty capsid	Kotecha et al., 2015
FMDV-A	4GH4	A₂₂/Iraq/24/64 (monolayer-cell-adapted) capsid [nt sequence]	Curry et al., 1996
	?	A₂₂/Iraq/24/64 (suspension-cell-adapted) capsid	Curry et al., 1996
	4IV1	A₂₂/Iraq/24/64 empty capsid	Porta et al., 2013
	4IV3	A₂₂/Iraq/24/64 empty capsid	Porta et al., 2013
	1ZBE	A₁₀/Arg/61 capsid	Fry et al., 2005
	1ZBA	A₁₀/Arg/61 capsid complexed With oligosaccharide receptor	Fry et al., 2005
	2BHG	A₁₀/Arg/61 3C^pro	Birtley et al., 2005
	2J92	A₁₀/Arg/61 3C^pro crystal packing mutant (K51q)	Sweeney et al., 2005
	5D8A	A22-H2093F empty capsid	Kotecha et al., 2015
FMDV-C	1FMD	C₁/Santa Pau/Spain/70 (C-S8c1) capsid	Lea et al., 1994a
	2D7S	C₁/Santa Pau/Spain/70 (C-S8c1) 3D^pol/VPg	Ferrer-Orta et al., 2004
	2F8E	C₁/Santa Pau/Spain/70 (C-S8c1) 3D^pol/uridylylated VPg	Ferrer-Orta et al., 2004
	1U09	C₁/Santa Pau/Spain/70 (C-S8c1) 3D^pol	Ferrer-Orta et al., 2004
	1QGC	C₁/Santa Pau/Spain/70 (C-S8c1) capsid complexed with a Fab fragment of a neutralizing antibody	Hewat et al., 1997
	N/A	C/Germany/c.26 (CGC) capsid [M90368]	Lea et al., 1994b
FMDV-SAT1	2WZR	SAT1/BOT/1/68 capsid [Z98203]	Adams et al., unpub.
FMDV-SAT2	5ACA	SAT2/ZIM/7/83 capsid [AF540910]	Kotecha et al., 2015
	5HM2	SAT2/GHA/8/91 3C^pro	Yang et al., 2016
FMDV	1BCV	Synthetic peptide corresponding to the major immunogen site of FMDV	Petit et al., 1999
	1BFW	Retro-inverso analogue of the FMDV VP1 G-H loop	Petit et al., 1999
	1EJO	Fab fragment of neutralising monoclonal antibody 4C4 complexed with G-H loop from FMDV	Ochoa et al., 2000

Equine rhinits A virus (ERAV)
Virus	PDB no.	Description [EMBL accession no.]	Reference
ERAV-1	2wff	Equine rhinitis A virus, NM-11/67	Tuthill et al., 2009
ERAV-1	2ws9	Equine rhinitis A virus at low pH, NM-11/67	Tuthill et al., 2009
ERAV-1	2xbo	Equine rhinitis A virus in complex with its sialic acid receptor	Fry et al., 2010
ERAV-1	4ctf	The limits of structural plasticity in a picornavirus capsid revealed by a massively expanded equine rhinitis A virus particle	Ranson et al., 2014
ERAV-1	4ctg	The limits of structural plasticity in a picornavirus capsid revealed by a massively expanded equine rhinitis A virus particle	Ranson et al., 2014

References

Acharya, R., Fry, E., Stuart, D., Fox, G., Rowlands, D. and Brown, F. (1989). The three-dimensional structure of foot-and-mouth disease virus at 2.9A resolution. Nature 337: 709-716.

Curry, S., Fry, E., Blakemore, W., Abu-Ghazaleh, R., Jackson, T., King, A., Lea, S., Newman, J., Rowlands, D. and Stuart, D. (1996). Perturbations in the surface structure of A22 Iraq foot-and-mouth disease virus accompanying coupled changes in host cell specificity and antigenicity. Structure 4: 135-145.

Fry, E.E., Tuthill, T.J., Harlos, K., Walter, T.S., Rowlands, D.J. and Stuart, D.I. (2010). Crystal structure of equine rhinitis A virus in complex with its sialic acid receptor. J Gen Virol. 91: 1971-1977.

Kotecha A, Seago J, Scott K, Burman A, Loureiro S, Ren J, Porta C, Ginn HM, Jackson T, Perez-Martin E, Siebert CA, Paul G, Huiskonen JT, Jones IM, Esnouf RM, Fry EE, Maree FF, Charleston B, Stuart DI. Structure-based energetics of protein interfaces guides foot-and-mouth disease virus vaccine design. Nat Struct Mol Biol. 2015 Oct;22(10):788-94. doi: 10.1038/nsmb.3096. Epub 2015 Sep 21. PMID: 26389739; PMCID: PMC5985953.

Lea, S., Hernandez, J., Blakemore, W., Brocchi, E., Curry, S., Domingo, E., Fry, E., Abu-Ghazaleh, R., King, A., Newman, J., Stuart, D. and Mateu, M.G. (1994a). The structure and antigenicity of a type C foot-and-mouth disease virus. Structure 2: 123-139.

Lea, S., Abu-Ghazaleh, R., Newman, J., Blakemore, W., Hernandez, J., Mateu, M.G., Domingo, E., King, A. and Stuart, D. (1994b). The structure of FMDV C-Ger/26 at 2.8A. Europic '94: VIIIth meeting of the European Study Group on the Molecular Biology of Picornaviruses, Korpilampi, Finland, 6-11 August 1994: abstract J11.

Lea, S., Abu-Ghazaleh, R., Blakemore, W., Curry, S., Fry, E., Jackson, T., King, A., Logan, D., Newman, J. and Stuart, D. (1995). Structural comparison of two strains of foot-and-mouth disease virus subtype O₁ and a laboratory antigenic variant, G67. Structure 3: 571-580.

Logan, D., Abu-Ghazaleh, R., Blakemore, W., Curry, S., Jackson, T., King, A., Lea, S., Lewis, R., Newman, J., Parry, N., Rowlands, D., Stuart, D., and Fry, E. (1993). Structure of a major immunogenic site on foot-and-mouth disease virus. Nature 362: 566-568.

Porta, C., Kotecha, A., Burman, A., Jackson, T., Ren, J., Loureiro, S., Jones, I.M., Fry, E.E., Stuart, D.I. and Charleston, B. (2013). Rational engineering of recombinant picornavirus capsids to produce safe, protective vaccine antigen. PLoS Pathog. 9(3):e1003255.

Ranson, N.A., Rowlands, D.J., Stockley, P.G., Pearson, A.R., Groppelli, E. and Bakker, S.E. (2014). Limits of structural plasticity in a picornavirus capsid revealed by a massively expanded equine rhinitis A virus particle. J.Virol. 88: 6093-6099.

Genus: Aphthovirus

References