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 Aphthovirus struct.

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Aphthovirus struct.
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Unassigned

VIPERdb - Virus Particle Explorer

Genus: Aphthovirus

FMDV-O 5-fold axis view FMDV-O 2-fold axis view FMDV-O 3-fold axis view

Foot-and-mouth disease virus (FMDV)

Virus PDB no. Description [EMBL accession no.] Reference
FMDV-O

 

1BBT O1/BFS 1860/UK/67 capsid [protein sequence] Acharya et al., 1989
1FOD O1/BFS 1860/UK/67 capsid (reduced) Logan et al., 1993
N/A O1/Kaufbeuren/FRG/66 capsid Lea et al., 1995
N/A O1/Kaufbeuren/FRG/66 (G67 variant) capsid Lea et al., 1995
1QOL O1/Kaufbeuren/FRG/66 Leader (Lb) protease Guarne et al., 1998
1QMY O1/Kaufbeuren/FRG/66 Leader (Lb) protease Guarne et al., 2000
1QQP O1/BFS 1860/UK/67 capsid complexed with oligosaccharide receptor Fry et al., 1999
FMDV-A 4GH4 A22/Iraq/24/64 (monolayer-cell-adapted) capsid [nt sequence] Curry et al., 1996
? A22/Iraq/24/64 (suspension-cell-adapted) capsid Curry et al., 1996
4IV1 A22/Iraq/24/64 empty capsid Porta et al., 2013
4IV3 A22/Iraq/24/64 empty capsid Porta et al., 2013
1ZBE A10/Arg/61 capsid Fry et al., 2005
1ZBA A10/Arg/61 capsid complexed With oligosaccharide receptor Fry et al., 2005
2BHG A10/Arg/61 3Cpro Birtley et al., 2005
2J92 A10/Arg/61 3Cpro crystal packing mutant (K51q) Sweeney et al., 2005
FMDV-C 1FMD C1/Santa Pau/Spain/70 (C-S8c1) capsid Lea et al., 1994a
2D7S C1/Santa Pau/Spain/70 (C-S8c1) 3Dpol/VPg Ferrer-Orta et al., 2004
2F8E C1/Santa Pau/Spain/70 (C-S8c1) 3Dpol/uridylylated VPg Ferrer-Orta et al., 2004
1U09 C1/Santa Pau/Spain/70 (C-S8c1) 3Dpol Ferrer-Orta et al., 2004
1QGC C1/Santa Pau/Spain/70 (C-S8c1) capsid complexed with a Fab fragment of a neutralizing antibody Hewat et al., 1997
N/A C/Germany/c.26 (CGC)  capsid [M90368] Lea et al., 1994b
FMDV-SAT1 2WZR SAT1/BOT/1/68 capsid [Z98203] Adams et al., unpub.
FMDV 1BCV Synthetic peptide corresponding to the major immunogen site of FMDV Petit et al., 1999
  1BFW Retro-inverso analogue of the FMDV VP1 G-H loop Petit et al., 1999
  1EJO Fab fragment of neutralising monoclonal antibody 4C4 complexed with G-H loop from FMDV Ochoa et al., 2000
     

Equine rhinits A virus (ERAV)

Virus PDB no. Description [EMBL accession no.] Reference
ERAV-1 2wff Equine rhinitis A virus, NM-11/67 Tuthill et al., 2009
ERAV-1 2ws9 Equine rhinitis A virus at low pH, NM-11/67 Tuthill et al., 2009
ERAV-1 2xbo Equine rhinitis A virus in complex with its sialic acid receptor Fry et al., 2010
ERAV-1 4ctf The limits of structural plasticity in a picornavirus capsid revealed
 by a massively expanded equine rhinitis A virus particle
Ranson et al., 2014
ERAV-1 4ctg The limits of structural plasticity in a picornavirus capsid revealed
 by a massively expanded equine rhinitis A virus particle
Ranson et al., 2014
       

References

Acharya, R., Fry, E., Stuart, D., Fox, G., Rowlands, D. and Brown, F. (1989). The three-dimensional structure of foot-and-mouth disease virus at 2.9A resolution. Nature 337: 709-716.

Curry, S., Fry, E., Blakemore, W., Abu-Ghazaleh, R., Jackson, T., King, A., Lea, S., Newman, J., Rowlands, D. and Stuart, D. (1996). Perturbations in the surface structure of A22 Iraq foot-and-mouth disease virus accompanying coupled changes in host cell specificity and antigenicity. Structure 4: 135-145.

Fry, E.E., Tuthill, T.J., Harlos, K., Walter, T.S., Rowlands, D.J. and Stuart, D.I. (2010). Crystal structure of equine rhinitis A virus in complex with its sialic acid receptor. J Gen Virol. 91: 1971-1977.

Lea, S., Hernandez, J., Blakemore, W., Brocchi, E., Curry, S., Domingo, E., Fry, E., Abu-Ghazaleh, R., King, A., Newman, J., Stuart, D. and Mateu, M.G. (1994a). The structure and antigenicity of a type C foot-and-mouth disease virus. Structure 2: 123-139.

Lea, S., Abu-Ghazaleh, R., Newman, J., Blakemore, W., Hernandez, J., Mateu, M.G., Domingo, E., King, A. and Stuart, D. (1994b). The structure of FMDV C-Ger/26 at 2.8A. Europic '94: VIIIth meeting of the European Study Group on the Molecular Biology of Picornaviruses, Korpilampi, Finland, 6-11 August 1994: abstract J11.

Lea, S., Abu-Ghazaleh, R., Blakemore, W., Curry, S., Fry, E., Jackson, T., King, A., Logan, D., Newman, J. and Stuart, D. (1995). Structural comparison of two strains of foot-and-mouth disease virus subtype O1 and a laboratory antigenic variant, G67. Structure 3: 571-580.

Logan, D., Abu-Ghazaleh, R., Blakemore, W., Curry, S., Jackson, T., King, A., Lea, S., Lewis, R., Newman, J., Parry, N., Rowlands, D., Stuart, D., and Fry, E. (1993). Structure of a major immunogenic site on foot-and-mouth disease virus. Nature 362: 566-568.

Porta, C., Kotecha, A., Burman, A., Jackson, T., Ren, J., Loureiro, S., Jones, I.M., Fry, E.E., Stuart, D.I. and Charleston, B. (2013). Rational engineering of recombinant picornavirus capsids to produce safe, protective vaccine antigen. PLoS Pathog. 9(3):e1003255.

Ranson, N.A., Rowlands, D.J., Stockley, P.G., Pearson, A.R., Groppelli, E. and Bakker, S.E. (2014). Limits of structural plasticity in a picornavirus capsid revealed by a massively expanded equine rhinitis A virus particle. J.Virol. 88: 6093-6099.

Tuthill, T.J., Harlos, K., Walter, T.S., Knowles, N.J., Groppelli, E., Rowlands, D.J., Stuart, D.I. and Fry, E.E. (2009). Equine rhinitis A virus and its low pH empty particle: clues towards an aphthovirus entry mechanism? PLoS Pathog. 2009 Oct;5(10):e1000620. Epub 2009 Oct 9.

 

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