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 Rhinovirus struct.

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Unassigned

VIPERdb - Virus Particle Explorer

Genus: Enterovirus
S
pecies: Rhinovirus A

HRV-A? 5-fold axis   |     HRV-A? 2-fold axis   |   HRV-A? 3-fold axis
     

Virus PDB no. Description [EMBL accession no.] Reference
HRV-A1A 1R1A 20601 (Ohio) [nt sequence] Kim et al., 1989
2HWD complexed with the antiviral agent WIN56291  
2HWF complexed with the antiviral agent R61837  
2HWE complexed with the antiviral agent WIN54954  
HRV-A2 1FPN Capsid  
2HRV 2A protease Petersen et al., 1999
1CQQ 3C protease  
HRV-A16 2RHN 11757 (Washington DC/60) [L24917] Oliviera et al., 1993; Hadfield et al., 1997
HRV-A16 1ND2   Zhang et al.
HRV-A16 1NCR HRV16 WHEN COMPLEXED WITH PLECONARIL Zhang et al.

References

Hadfield, A.T., Lee, W., Zhao, R., Oliveira, M.A., Minor, I., Rueckert, R.R. and Rossmann, M.G. (1997). The refined structure of human rhinovirus 16 at 2.15 A resolution: implications for the viral life cycle. Structure 15: 427-441.

Kim, S., Smith, T.J., Chapman, M.S., Rossmann, M.G., Pevear, D.C., Dutko, F.J., Felock, P.J., Diana, G.D. and McKinlay, M.A. (1989). Crystal structure of human rhinovirus serotype 1A (HRV1A). J. Mol. Biol. 210: 91-111.

Matthews, D.A., Smith, W.W., Ferre, R.A., Condon, B., Budahazi, G., Sisson, W., Villafranca, J.E., Janson, C.A., McElroy, H.E., Gribskov, C.L. and Worland, S. (1994). Structure of human rhinovirus 3C protease reveals a trypsin-like polypeptide fold, RNA-binding site, and means for cleaving precursor polyprotein. Cell 77: 761-771.

Oliviera, M.A., Zhao, R., Lee, W-M., Kremer, M.J., Minor, I., Rueckert, R.R., Diana, G.D., Pevear, D.C., Dutko, F.J., McKinlay, M.A. and Rossmann, M.G. (1993). The structure of human rhinovirus 16. Structure 1: 51-68.


Genus: Enterovirus
Species:
Rhinovirus B

HRV-B14 5-fold axis     |         HRV-B14 2-fold axis     |       HRV-B14 3-fold axis

       
 
Virus PDB no. Description [EMBL accession no.] Reference
HRV-B3 1RHI ? [U60874] Zhao et al., 1996
HRV-B14

 

4RHV 1059 (South Carolina/59) [K02121, K01087, L05355] Rossmann et al., 1985
1HRI complex with antiviral agent sch 38057  
1HRV complexed with sdz 35-682  
1R08 complex with antiviral agent WIN viii$  
1R09 complex with antiviral agent WIN R61837  
1RMU (mutant with cys 1 199 replaced by tyr) (/c199y$ in chain 1)  
1RUC mutation: n(1)105s; heterogen: antiviral agent WIN 52035  
1RUD mutation: n(1)105s; heterogen: antiviral agent WIN 52084  
1RUE mutation: n(1)219a; heterogen: antiviral agent WIN 52035  
1RUF mutation: n(1)219a  
1RUG mutation: n(1)219s; heterogen: antiviral agent WIN 52035  
1RUH mutation: n(1)219s; heterogen: antiviral agent WIN 52084  
1RUI mutation: s(1)223g; heterogen: antiviral agent WIN 52084  
1RUJ mutation: s(1)223g  
2HWB mutant with ile 2 170 replaced by val 2 (i(2 170)v) complexed with the antiviral agent WIN 56291  
2HWC mutant with ile 2 170 replaced by val 2 (i(2 170)v) complexed with the antiviral agent WIN 54954  
2R04 complex with antiviral agent WIN iv$  
2R06 complex with antiviral agent WIN vi$  
2R07 complex with antiviral agent WIN vii$  
2RM2 complex with antiviral agent WIN ii(s/r)$  
2RMU (mutant with val 1 188 replaced by 2 leu) (/v188l$ in chain 1)  
2RR1 complex with antiviral agent WIN i(r)$  
2RS1 complex with antiviral agent WIN i(s)$  
2RS3 complex with antiviral agent WIN iii(s)$  
2RS5 complex with antiviral agent WIN v(s)$  
HRV-B14 1NCQ HRV14 WHEN COMPLEXED WITH PLECONARIL Zhang et al.
HRV-B14 N/A 3C proteinase Matthews et al., 1994
HRV-B14 1IK1 Solution structure of an RNA hairpin from HRV-14  
       

References

Rossmann, M.G., Arnold, E., Erickson, J.W., Frankenberger, E.A., Griffith, J.P., Hecht, H.-J., Johnson, J.E., Kamer, G., Luo, M., Mosser, A.G., Rueckert, R.R., Sherry, B. and Vriend, G. (1985). Structure of a human common cold virus and functional relationship to other picornaviruses. Nature 317: 145-153.

Zhao, R., Pevear, D.C., Kremer, M.J., Giranda, V.L., Kofron, J., Rossmann, M.G. and Kuhn, R.J. (1996). The structure of human rhinovirus 3 at 3.0 A resolution. Structure 4: 1205-1220.


Genus: Enterovirus
Species:
Rhinovirus C

       |        

Virus PDB no. Description [EMBL accession no.] Reference
HRV-C15 5K0U CryoEM structure of the full virion of a human rhinovirus C Liu et al., 2016
HRV-C15 5JZG CryoEM structure of the native empty particle of a human rhinovirus C Liu et al., 2016
       

References

Liu Y, Hill MG, Klose T, Chen Z, Watters K, Bochkov YA, Jiang W, Palmenberg AC, Rossmann MG. Atomic structure of a rhinovirus C, a virus species linked to severe childhood asthma. Proc Natl Acad Sci U S A. 2016 Aug 9;113(32):8997-9002. doi: 10.1073/pnas.1606595113. Epub 2016 Jul 11. PubMed PMID: 27511920; PubMed Central PMCID: PMC4987780.

 
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