The
Picornavirus
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Child level |
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Genera |
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The species
Enterovirus G (formerly named Porcine
enterovirus B) consists of a twenty
(sero)types: EV-G1 to EV-G20 (Table
1).
The original porcine enterovirus (PEV) 1 to 7 and 11 to 13 have been reclassified and assigned to a new genus, Teschovirus; PEV-8 has been renamed porcine sapelovirus 1 and reclassified in the species Sapelovirus A, genus Sapelovirus. Examples of EV-G1 (KY498016, KY498017, KY214435 plus 16 others), G2 (LC316791) and EV-G17 (KY761948) have been found which contain an inserted porcine torovirus-like papain-like cysteine protease (PLCP) coding region inserted between 2C and 3A (Conceição-Neto et al., 2017; Knutson et al., 2017; Shang et al., 2017; Tsuchiaka et al., 2018). Interestingly the PLCP regions in the two virus types (G1 and G17) only share 87% nt and 86% aa identities. A recently described enterovirus found in a goat in China (Wang et al., 2017) has been designated as a new type, EV-G20. Table 1.
References Conceição-Neto N, Theuns S, Cui T, Zeller M, Yinda CK, Christiaens I, Heylen E, Van Ranst M, Carpentier S, Nauwynck HJ, Matthijnssens J. Identification of an enterovirus recombinant with a torovirus-like gene insertion during a diarrhea outbreak in fattening pigs. Virus Evol. 2017 Sep 8;3(2):vex024. doi: 10.1093/ve/vex024. eCollection 2017 Jul. PubMed PMID: 28924489; PubMed Central PMCID: PMC5591953. Knutson, T.P., Velayudhan, B.T., Marthaler, D.G. (2017). A porcine enterovirus G associated with enteric disease contains a novel papain-like cysteine protease. J. Gen. Virol. 98: 1305-1310. doi: 10.1099/jgv.0.000799. Shang, P., Misra, S., Hause, B., Fang, Y. (2017). A naturally occurring recombinant enterovirus expresses a torovirus deubiquitinase. J. Virol. 2017 May 10. pii: JVI.00450-17. doi: 10.1128/JVI.00450-17. [Epub ahead of print] Tsuchiaka S, Naoi Y, Imai R, Masuda T, Ito M, Akagami M, Ouchi Y, Ishii K, Sakaguchi S, Omatsu T, Katayama Y, Oba M, Shirai J, Satani Y, Takashima Y, Taniguchi Y, Takasu M, Madarame H, Sunaga F, Aoki H, Makino S, Mizutani T, Nagai M. Genetic diversity and recombination of enterovirus G strains in Japanese pigs: High prevalence of strains carrying a papain-like cysteine protease sequence in the enterovirus G population. PLoS One. 2018 Jan 11;13(1):e0190819. doi: 10.1371/journal.pone.0190819. eCollection 2018. PubMed PMID: 29324778; PubMed Central PMCID: PMC5764308.Wang, M., He, J., Lu, H., Liu, Y., Deng, Y., Zhu, L., Guo, C., Tu, C. and Wang, X. (2017). A novel enterovirus species identified from severe diarrheal goats. PLoS One 12(4): e0174600. doi: 10.1371/journal.pone.0174600. |